Gene information
Official symbol PLA2G2A
Official full name phospholipase A2 group IIA
Gene type protein-coding gene
Chromosome1p36.13
Previous symbolPLA2B; PLA2L
Gene familyPhospholipases
Resources
Entrez Gene 5320
HGNC HGNC:9031
Ensembl ENSG00000188257
Vega OTTHUMG00000002699
UCSC uc001bcv.4
GO terms: 29 records
GO Description Category LogP Number of genes Detail
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0004623 phospholipase A2 activity GO Molecular Functions -2.0068648 3 More
GO:0005509 calcium ion binding GO Molecular Functions -14.7764642 80 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0006644 phospholipid metabolic process GO Biological Processes -2.96272379 13 More
GO:0006650 glycerophospholipid metabolic process GO Biological Processes -2.76007072 11 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0019835 cytolysis GO Biological Processes -3.83961894 4 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0046470 phosphatidylcholine metabolic process GO Biological Processes -5.57583811 8 More
GO:0046486 glycerolipid metabolic process GO Biological Processes -5.86759713 18 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048872 homeostasis of number of cells GO Biological Processes -12.0072872 22 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050830 defense response to Gram-positive bacterium GO Biological Processes -13.1972375 17 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:1902563 regulation of neutrophil activation GO Biological Processes -3.04620727 3 More
KEGG pathways: 4 records
KEGG Description Category LogP Number of genes Detail
hsa00565 Ether lipid metabolism KEGG Pathway -1.58061219 3 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04270 Vascular smooth muscle contraction KEGG Pathway -11.6218936 17 More
hsa04975 Fat digestion and absorption KEGG Pathway -5.93899775 11 More
Drug-Gene interaction
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Related drugs: 7 records
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
phospholipase A2, membrane associated proteomics death[prognosis (bad)] acute myocardial infarction Xin H et al. Eur Rev Med Pharmacol Sci. 2013
phospholipase A2, membrane associated proteomics rosuvastatin[treatment (pharmacotherapy)] acute myocardial infarction Ren Y et al. Exp Ther Med. 2017
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